- UFC 259 will be Blachowicz's maiden title defense. He won the vacant 205-pound belt at UFC 253 in September by knocking out Dominick Reyes in the second round.
- The undefeated Adesanya headlined that same fight card. He successfully defended the 185-pound belt by knocking out Paulo Costa in the third round.
- If Adesanya comes out victorious, he will be part of an elite group of UFC fighters who've held two titles simultaneously. There are currently four "champ-champs" in company history: Conor McGregor, Daniel Cormier Henry Cejudo, and Amanda Nunes.